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Inhibition of localized thrombosis in P2Y 1 ‐deficient mice and rodents treated with MRS2179, a P2Y 1 receptor antagonist
Author(s) -
Lenain N.,
Freund M.,
Léon C.,
Cazenave J.P.,
Gachet C.
Publication year - 2003
Publication title -
journal of thrombosis and haemostasis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.947
H-Index - 178
eISSN - 1538-7836
pISSN - 1538-7933
DOI - 10.1046/j.1538-7836.2003.00144.x
Subject(s) - antagonist , pharmacology , thrombosis , receptor , receptor antagonist , medicine , chemistry
Summary. Previous studies in experimental models revealed a role for the P2Y 1 platelet ADP receptor in systemic vascular thromboembolism models. In the present work, we used models of localized arterial and venous thrombosis to assess the role of the P2Y 1 receptor in these processes. Arterial thrombosis was induced in one mesenteric arteriole of a mouse using FeCl 3 , while venous thrombosis was studied in a Wessler model adapted to rats. P2Y 1 ‐deficient mice and mice treated with the P2Y 1 antagonist MRS2179 displayed significantly less arterial thrombosis than their respective controls. Combination of P2Y 1 deficiency with P2Y 12 inhibition led to a significant additive effect. Venous thrombosis was slightly but significantly inhibited in MRS2179‐treated rats. These results demonstrate a role for the P2Y 1 receptor in both arterial and venous thrombosis, further establishing this receptor as a potential target for antithrombotic drugs.