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Posttransfusion purpura secondary to an alloantibodyreactive with HPA‐5a (Br b )
Author(s) -
Anolik Jennifer Howitt,
Blumberg Neil,
Snider John,
Francis Charles W.
Publication year - 2001
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.2001.41050633.x
Subject(s) - medicine , platelet , antibody , purpura (gastropod) , typing , immunology , cardiopulmonary bypass , platelet transfusion , biology , genetics , ecology
BACKGROUND: Posttransfusion purpura (PTP) is characterized by severe thrombocytopenia following blood transfusion that results from alloimmunization to platelet‐specific alloantigens. Most cases involve antibodies against HPA‐1a in homozygous HPA‐1b persons. CASE REPORT: A patient developed PTP after cardiopulmonary bypass associated with a platelet‐specific antibody with strong reactivity against HPA‐5a (Br b ). Geno‐typing confirmed that the patient was homozygous for HPA‐5b. CONCLUSION: This is the first well‐documented occurrence of PTP associated with isolated allosensitization to HPA‐5a or Br b . The case highlights the importance of maintaining a high level of suspicion for PTP in the appropriate clinical setting, even in an atypical patient.