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Donor age‐related differences in PBPC mobilization with rHuG–CSF
Author(s) -
De la Rubia Javier,
Díaz Miguel A.,
Verdeguer Amparo,
Pascual Maria J.,
Arbona Cristina,
Arrieta Rosario,
Brunet Salut,
Bargay Joan,
Martínez Carmen,
Espigado Ildefonso,
Serrano David,
Alegre Adrián,
De Arriba Felipe,
De la Serna Javier,
Zamora Concha,
Benlloch Luis,
Sanz Miguel A.
Publication year - 2001
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.2001.41020201.x
Subject(s) - medicine , apheresis , group b , mobilization , gastroenterology , group a , surgery , platelet , archaeology , history
BACKGROUND: Data on the administration of rHuG–CSF to normal donors <18 years old are very limited. STUDY DESIGN AND METHODS: The results of rHuG–CSF administration to 61 donors <18 years old (Group A) were retrospectively evaluated and compared with results from 353 donors ≥18 years old (Group B) who are included in the Spanish National Donor Registry. The mean age (range) in Group A and B was 14 (1‐17) and 38 (18‐71) years, respectively (p<0.001). The mean dose of rHuG–CSF was 10 μg per kg per day (range, 9‐16) during a mean of 5 days (range, 4‐6). Central venous access was placed more frequently in younger donors (25% vs. 6%; p<0.001). RESULTS: The mean number of CD34+ cells collected was 7.6 and 6.9 × 10 6 per kg of donor′s body weight in Group A and B, respectively. Fifty‐six percent of Group A donors needed only one apheresis to achieve ≥4 × 10 6 CD34+ cells per kg versus 39 percent of Group B donors (p = 0.01). Side effects were more common in Group B (71% vs. 41%; p<0.001). CONCLUSION: The administration of rHuG–CSF to donors <18 years old leads to CD34+ cell mobilization in a pattern similar to that observed in adults. Greater age was associated with a more frequent requirement for more than one apheresis to achieve a similar number of CD34+ cells.