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Acute intravascular hemolysis secondaryto out‐of‐group platelet transfusion
Author(s) -
Larsson L.G.,
Welsh V.J.,
Ladd D.J.
Publication year - 2000
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.2000.40080902.x
Subject(s) - hemolysis , medicine , abo blood group system , platelet , hemoglobinuria , apheresis , platelet transfusion , titer , acute leukemia , gastroenterology , transfusion medicine , immunology , blood transfusion , leukemia , antibody
BACKGROUND: Acute intravascular hemolysis is rarely associated with platelet transfusion. Out‐of‐group single‐donor platelets may cause hemolysis if the donor has high‐titer ABO hemagglutinins. CASE REPORT: A 44‐year‐old woman, blood group A, was recently diagnosed with acute myeloid leukemia and was receiving chemotherapy. After the transfusion of apheresis platelets from a group O donor, back pain, hemoglobinuria, and hemoglobinemia developed, and her Hb dropped by 2.3 g per dL, despite the transfusion of 2 units of RBCs. RESULTS: Investigation revealed acute intravascular hemolysis with a positive DAT due to anti‐A 1 on her RBCs. The donor's titer of anti‐A 1 was greater than 16,000. CONCLUSION: Review of published cases raises the possibility that hemolytic reactions to out‐of‐group platelets may be more frequent since the use of apheresis platelets has increased.