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The number of platelet glycoprotein Ia molecules is associated with the genetically linked 807 C/T and HPA‐5 polymorphisms
Author(s) -
Corral Javier,
Rivera José,
GonzálezConejero Rocio,
Vicente Vicente
Publication year - 1999
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1999.39499235668.x
Subject(s) - platelet membrane glycoprotein , allele , platelet , immunology , glycoprotein , gene , microbiology and biotechnology , biology , genetics
BACKGROUND: The neutral 807 C/T (Phe 224 ) polymorphism (807 C/T polymorphism) of the glycoprotein (GP)Ia gene has been recently associated with the number of GPIa molecules on the platelet surface. The association of the number of GPIa molecules with other GPIa polymorphisms, such as HPA‐5 (Glu/Lys 505 ) (HPA‐5 polymorphism), involved in alloimmune thrombocytopenias is unknown. STUDY DESIGN AND METHODS: The association of the HPA‐5 polymorphism with the number of GPIa molecules on the platelet surface in 159 white blood donors was investigated. The genetic linkage between the HPA‐5 and the 807 C/T polymorphisms in 316 individuals was also determined. RESULSTS: Both the 807 C/T and HPA‐5 polymorphisms correlate with the number of GPIa molecules on the platelet surface. The 807 T and HPA‐5b alleles are associated with increased numbers of GPIa molecules on the platelet surface. Moreover, the HPA‐5b allele is genetically linked to 15.8 percent of the 807 C alleles. Therefore, the number of GPIa molecules on the platelet surface is dependent on both GPIa polymorphisms as follows: 807 T/T , HPA‐5 a/a > 807 C/T , HPA‐5 a/b > 807 C/T , HPA‐5 a/a > 807 C/C , HPA‐5 a/b > 807 C/C , HPA‐5 a/a. CONCLUSION: Two GPIa polymorphisms (807 C/T and HPA‐5) responsible for the variability in the numbers of GPIa/lla molecules on the platelet surface in whites have been identified. Despite the genetic linkage between the two polymorphisms, their influence on the number of GPIa molecules on the platelet surface may occur through different mechanisms.