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Relationship of the time of storage and transfusion reactions to platelet concentrates from buffy coats
Author(s) -
Riccardi D.,
Raspollini E.,
Rebulla P.,
Pappalettera M.,
Marangoni F.,
Greppi N.,
Sirchia G.
Publication year - 1997
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1997.37597293886.x
Subject(s) - medicine , buffy coat , platelet , white blood cell , blood transfusion , platelet transfusion , relative risk , surgery , confidence interval
BACKGROUND : Transfusion reactions to platelet concentrates prepared from buffy coats (BC‐PCs) were reviewed to determine the effect of some variables of BC‐PC preparation and storage: time of BC storage before BC‐PC preparation (1–2 days); time of BC‐PC storage before transfusion (1–5 days); no white cell reduction versus laboratory and bedside BC‐PC white cell reduction. STUDY DESIGN AND METHODS : A multiple linear logistic regression model was used by which the relative effect of one variable is expressed as the relative risk of transfusion reaction against a baseline level (1‐day storage, no white cell reduction). RESULTS : During the 14 months of study, a total of 2707 BC‐PC transfusions were given to 192 patients; 37 reactions (1.4%) were reported in 25 patients (13%). The transfusion reactions were febrile, nonhemolytic in 23 cases; allergic in 5; febrile and allergic in 2; and other in 7. The relative risk of transfusion reaction to BC‐PCs prepared from BCs stored for 2 days was 1.98 times that to BC‐PCs prepared from BCs stored for 1 day (p = 0.07). The relative risk of transfusion reaction of 5‐day‐old BC‐PCs was 10.7 times that of 1‐day‐ old BC‐PCs (p = 0.001). The relative risk of transfusion reactions of BC‐PCs white cell‐reduced in the laboratory and at the bedside were 0.65 (p = 0.3) and 1.87 (p = 0.1) times, respectively, that of non‐ white cell‐reduced BC‐PCs. CONCLUSION : Time of storage seems to be an important variable associated with BC‐PC transfusion reaction.