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High frequency of HLA‐A*0207 subtype in Chinese population
Author(s) -
Shieh D.C.,
Lin D.T.,
Yang B.S.,
Kuan H.L.,
Kao K.J.
Publication year - 1996
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1996.36996420761.x
Subject(s) - human leukocyte antigen , allele frequency , population , polymerase chain reaction , genetics , chinese population , biology , hla a , allele , immunology , medicine , gene , genotype , antigen , environmental health
Background: HLA‐A2 is the most polymorphic and most common HLA phenotype found in various ethnic populations. Seventeen HLA‐A2 subtypes have been reported and characterized by molecular techniques. Differences among these subtypes are limited to a few amino acids. Among them, HLA‐A*0201 is the predominant subtype among whites. The results of a recent study, however, suggest that the HLA‐A*0207 subtype may be present at a high frequency in the Chinese population. Study Design and Methods: To determine the exact frequency of the HLA‐A*0207 Sep s1996 Septype in the Chinese population, genomic DNA samples obtained from 54 HLA‐A2‐positive Chinese in Taiwan were studied by using sequence‐specific primers and polymerase chain reaction. Results: HLA‐A*0207 was present in 56 percent of the studied subjects. The estimated gene frequency for HLA‐A*0207 is 17.8 percent in the Chinese population. Conclusion: HLA‐A*0207 is the most common HLA‐A2 subtype among Chinese. The high frequency of the HLA‐A*0207 allele in this population offers a unique opportunity to study the ways in which different HLA‐A2 subtypes may influence the clinical outcome of allograft transplantation and the disease susceptibility of recipients.