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Gene frequencies of human platelet antigens on glycoprotein IIIa in Japanese
Author(s) -
Tanaka S.,
Ohnoki S.,
Shibata H.,
Okubo Y.,
Yamaguchi H.,
Shibata Y.
Publication year - 1996
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1996.36996420760.x
Subject(s) - neonatal alloimmune thrombocytopenia , platelet membrane glycoprotein , antigen , immunology , platelet , typing , human leukocyte antigen , platelet transfusion , glycoprotein , gene , medicine , biology , genetics , pregnancy , fetus
Background: Polymorphism of glycoprotein IIIa on human platelets is one of the factors in alloimmunization that causes neonatal alloimmune thrombocytopenia and refractoriness to platelet transfusion. Study Design and Methods: DNA typing methods were originally developed to determine the genotypes of five human platelet antigen (HPA) systems located on glycoprotein IIIa: HPA‐1, HPA‐4, HPA‐6W, HPA‐7W and HPA‐8W. The gene frequencies of these platelet antigens were determined by DNA typing of 331 unrelated Japanese donors. Results: The gene frequencies of the low‐frequency antigens were 0.002, 0.011, and 0.027 for HPA‐1b, HPA‐4b , and HPA‐6W(b) , respectively. All 331 Japanese donors tested were HPA‐7W(a/a) and HPA‐8W(a/a) . Moreover, in the present study, none of the donors tested had two or more of these low‐frequency antigens. Conclusion: The risk of neonatal alloimmune thrombocytopenia and refractoriness to platelet transfusion induced by the antigens of the HPA‐1, HPA‐7W, and HPA‐8W systems was extremely rare in Japanese. However, attention must be paid to the involvement of the HPA‐4 and HPA‐6W systems in these clinical disorders.