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Hemolytic disease of the newborn due to the Scianna antibody, anti‐Sc2
Author(s) -
DeMarco Marianne,
Uhl Lynne,
Fields Lore,
Pacini Donna,
Gorlin Jed B.,
Kruskall Margot S.
Publication year - 1995
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1995.35195090664.x
Subject(s) - hemolysis , medicine , hematocrit , antibody , immunology , red blood cell , abo blood group system , coombs test , red cell , hemolytic disease of the newborn (abo) , immune system , antigen , isoantibodies , hemolytic anemia , pregnancy , biology , fetus , genetics
BACKGROUND: Alloantibodies to the low‐frequency antigen Scianna 2 (Sc2) are uncommon and not previously reported to cause immune hemolysis. CASE REPORT: A group B, Rh‐negative infant born to a group B, Rh‐ positive mother had a 2+ direct antiglobulin test, as well as modest hyperbilirubinemia and a hematocrit of 45 percent. Ongoing immune hemolysis led to a hematocrit of 17.3 percent on Day 20 of life, and the infant required hospitalization and red cell transfusions. The routine maternal antibody screen was negative, but anti‐Sc2 was detected during work‐up for a low‐frequency red cell antigen, and the father's red cells typed as Sc:1,2. CONCLUSION: Anti‐Sc2 can cause clinically significant hemolytic disease of the newborn. Although the antibody is uncommon, its frequency and hemolytic potential may be underappreciated, in part because investigations often are not carried out in the infant whose red cells are ABO‐incompatible with maternal blood.