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Frequency of platelet‐specific antigens among Indonesians
Author(s) -
Santoso S.,
Santoso S.,
Kiefel V.,
Masri R.,
MuellerEckhardt C.
Publication year - 1993
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1993.33994025024.x
Subject(s) - antigen , nak , platelet , glycoprotein , immunology , indonesian , platelet membrane glycoprotein , monoclonal antibody , antibody , immunoassay , phenotype , medicine , biology , microbiology and biotechnology , genetics , gene , telecommunications link , computer network , linguistics , philosophy , computer science
This study reports the frequencies of the alloantigens of four major platelet‐specific alloantigen systems among Indonesians. One hundred and sixty‐eight unrelated Indonesian blood donors were phenotyped for the alloantigens of the Zw (PIA, HPA‐1), Bak (HPA‐3), Yuk (Pen, HPA‐4), and Br (HPA‐5) systems by use of a glycoprotein‐specific immunoassay. All were positive for the alloantigens Zwa, Yukb, and Brb. Three (1.79%) and 1 (0.59%) of the 168 donors were positive in testing for Zwb and Yuk(a) antigens, respectively. Fifteen (9.26%) of 162 Indonesians had Br(a) antigens. Of the 166 donors tested, 121 (72.89%) were Bak(a) positive and 134 (80.72%) were Bakb positive. In addition, the phenotype frequency of Nak(a) was determined by using monoclonal antibody OKM5 in a platelet enzyme‐linked immunosorbent assay. Its frequency in the present cohort was 95.83 percent (161/168). This study confirms the differences in platelet antigen distributions in Asians and whites. Both glycoprotein IV deficiency and the Yuk polymorphism are also found among Indonesians.