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Too much of a good thing?
Author(s) -
Bove Joseph R.
Publication year - 1993
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1993.33793325047.x
Subject(s) - haven , medicine , surgery , art history , nuclear medicine , art , combinatorics , mathematics
p53 is known to be a tumor suppressor, but the extent of its influence might be more crucial than has been realized. A recent report confirms that too little p53 results in cancer, but also unequivocally suggests that too much p53 markedly accelerates the acquisition of characteristics associated with the aging process. These findings indicate that a precisely tuned level of p53 activity is necessary for a long cancer-free life, and could have major implications for cancer treatment strategies.