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IgA cold agglutinins recognize Pr and Sa antigens expressed on glycophorins
Author(s) -
Roelcke D.,
Hack H.,
Kreft H.,
Macdonald B.,
Pereira A.,
Habibi B.
Publication year - 1993
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1993.33693296808.x
Subject(s) - isotype , kappa , glycophorin , glycan , cold agglutinin , antibody , antigen , immunology , biology , microbiology and biotechnology , glycoprotein , monoclonal antibody , mathematics , geometry
Three cases of IgAκ cold agglutinins (CAs) were studied. One had anti‐Pr 1 specificity, one had anti‐Pr a , and one had anti‐Sa. The CAs recognize O‐glycans of glycophorins. The findings supplement previous data on anti‐Pr 1 specificities of four IgAκ CAs. Because all IgA kappa CAs described recognize O‐glycans of glycophorins, a close association between the CA IgA isotype and specificities for O‐glycans becomes apparent. It is unlikely, however, that the striking association reflects interrelations between IgA CA structure and specificity, because anti‐Sa specificity and all anti‐Pr subspecificities were originally defined with IgM CAs.