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Plateletpheresis: comparison of platelet yields, processing time, and white cell content with two apheresis systems
Author(s) -
Burgstaler E.A.,
Pineda A.A.,
Brecher M.A.
Publication year - 1993
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1993.33593255599.x
Subject(s) - apheresis , plateletpheresis , platelet , platelet concentrate , chemistry , analytical chemistry (journal) , medicine , chromatography
Two apheresis systems (COBE Spectra and Fenwal CS‐3000 Plus with TNX‐6 chamber [CS‐3000 Plus]) were compared by using their yield predictors and maximum processing times in regard to platelet yields and processing times (n = 200 each). Platelet yields (n = 50 each) and white cell (WBC) content (n = 20 each) from procedures using the current software revision (3.6) on the Spectra and various interface offset (IO) settings on the CS‐3000 Plus were also compared. Significantly higher median platelet yields (4.88 [range, 1.84‐9.97] vs. 4.57 [range, 2.82‐9.20] × 10(11) platelets) and frequency of components with > or = 6.0 × 10(11) platelets (31.5 vs. 21.5%) were found with the Spectra. In the study with Spectra and the CS‐3000 Plus IO settings, IO‐10 and IO‐13, overall, produced the most platelets, although the differences were not significant. All Spectra collections tested had < 5 × 10(8) WBCs, and, depending on the software revision, had either 85 percent (revision 3.6) or 100 percent (revision 2.5) of components with < 5 × 10 6 WBCs. To ensure that 100 percent of components contained < 5 × 10 8 WBCs when the CS‐3000 Plus was used, IO settings of 10 or less were required, and to ensure components with < 5 × 10(6) WBCs, only IO‐6 could be used. Spectra and CS‐3000 Plus were capable of collecting large doses of platelets (up to the equivalent of 18 units) in processing times of 67 to 100 minutes with < 5 × 10 6 WBCs.