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Pretransfusion incubation of apheresis platelets at 37°C improves posttransfusion recovery
Author(s) -
SHANWELL A.,
WIKMAN A.,
RINGDBN O.
Publication year - 1992
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1992.32893032097.x
Subject(s) - apheresis , platelet , incubation , medicine , plateletpheresis , incubation period , anesthesia , platelet transfusion , surgery , chemistry , biochemistry
The effect of brief 37 degrees C pretransfusion incubation of apheresis platelets (n = 25) was studied in 14 allogenic bone marrow transplant recipients (5 children, 9 adults). Apheresis platelets were collected on a cell separator, divided in two aliquots, and stored 1 to 5 days at 22 degrees C during agitation. One aliquot was incubated at 37 degrees C for 1 hour before transfusion, and the other was transfused as a paired control. When the patient's peripheral platelet count fell below 30 × 10(9) per L, one aliquot was transfused. The other aliquot was transfused the following day. Each patient received the two aliquots in random order. Corrected count increment (CCI) at 1 hour after transfusion of 37 degrees C incubated platelets was 12.2 +/− 9.5 (mean +/− SD) compared to 7.5 +/− 5.4 for paired control platelets (p < 0.05). CCIs the next day were 4.4 +/− 6.1 and 2.4 +/− 2.7, respectively (not significant). It can be concluded that 37 degrees C incubation of apheresis platelets improves posttransfusion CCI.