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Fibrin glue from single‐donation autologous plasmapheresis
Author(s) -
Casali B.,
Rodeghiero F.,
Tosetto A.,
Palmieri B.,
Immovilli R.,
Ghedini C.,
Rivasi P.
Publication year - 1992
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1992.32792391037.x
Subject(s) - plasmapheresis , fibrin glue , fibrinogen , saline , fibrin , apheresis , medicine , surgery , plasma volume , chemistry , anesthesia , immunology , platelet , antibody
A method is described for preparing fibrin glue from fibrinogen obtained by double cryoprecipitation of plasma collected by plasmapheresis. Plasma (average volume, 528.8 +/− 86 mL), collected from 12 plasmapheresis donors was cryoprecipitated twice. When the cryoprecipitated pellet was resuspended in 0.5 to 2 mL of saline (total volume of saline‐resuspended fibrinogen: 5 mL), the average yield of fibrinogen was 78.4 +/− 18.3 mg per mL. This is comparable to commercial preparations, is suitable for clinical use, and offers greater safety at a reduced cost.