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Transfusion‐associated graft‐versus‐host disease in a presumably immunocompetent patient after transfusion of stored packed red cells
Author(s) -
SUZUKI K.,
AKIYAMA H.,
TAKAMOTO S.,
MARUYAMA Y.,
SAKAMAKI H.,
AKAGI K.,
MAEDA Y.,
TAKENAKA M.,
ONOZAWA Y.
Publication year - 1992
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1992.32492263452.x
Subject(s) - medicine , human leukocyte antigen , packed red blood cells , blood transfusion , typing , disease , graft versus host disease , immunology , population , pathology , biology , antigen , genetics , environmental health
A 54‐year‐old woman developed transfusion‐associated graft‐versus‐host disease (TA‐GVHD) after the transfusion of stored packed red cells obtained from unrelated donors. The patient was presumed to be immunocompetent. A diagnosis of TA‐GVHD was made by clinical features and postmortem pathologic findings. Sex chromatin analysis of the patient's lymphocytes demonstrated chimerism. HLA typing of the blood donors revealed one to be HLA‐homozygous for one of the patient's HLA haplotypes (A33‐B44‐Cblank). This case illustrates the risk in the general patient population of TA‐GVHD after routine blood transfusion therapy. Workers should be aware of this possibility and should continue searching for an efficient way to prevent it.