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Effects on donors of second bone marrow collections
Author(s) -
Stroncek D.F.,
McGlave P.,
Ramsay N.,
McCulloug J.
Publication year - 1991
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1991.31992094669.x
Subject(s) - medicine , bone marrow , donation , complication , homologous chromosome , surgery , transplantation , red cell , blood donations , incidence (geometry) , blood transfusion , biology , biochemistry , economics , gene , economic growth , physics , optics
Second bone marrow transplants have been used successfully to treat marrow graft failure or relapse following the original marrow transplantation. Hospital records of 16 related two‐time bone marrow donors were reviewed to determine what risks a person faces in making a second marrow donation. One donor suffered a minor complication following the first collection, but no donors suffered complications during the second donation. The volume of marrow collected for the first and second donations (1253 +/− 504 vs. 1261 +/− 471 mL) was similar. However, more marrow donors received transfusions of homologous red cells during the second collection than during the first collection (5/16 compared to 1/16; p = 0.06). To determine what factors might contribute to the high incidence of homologous red cell transfusion during second donations, the experiences of donors who received homologous blood during the second donation were compared to the experiences of donors who received only autologous blood. Persons receiving homologous blood during the second collection received more red cell units than persons receiving autologous blood (2.0 +/− 0.7 units compared to 0.9 +/− 0.5 units; p < 0.01). Their precollection hemoglobin levels were lower (12.3 +/− 1.2 vs. 14.4 +/− 1.4 g/dL [123 +/− 12 vs. 144 +/− 14 g/L]; p < 0.01), and the time between the first and second collections was significantly less (45 +/− 8 days vs. 342 +/− 432 days; p < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)). Further analysis showehat five of eight persons who donated marrow a second time within 60 days of the first donation were transfused with homologous blood, while none of eight persons who donated bone marrow more than 60 days after their first donation were transfused with homologous blood (p<0.05). These results suggest that people can safely do‐ nate marrow a second time; however, if the second marrow collection occurs within 60 days of the first collection, precautions should be taken to reduce the chances of exposing the marrow donor to homologous blood.