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Rh33 in two of three German siblings with D+ C+ c+ E− e+ red cells
Author(s) -
Moores P.,
Smart E.,
Sternberger J.,
Schneider W.
Publication year - 1991
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1991.31892023505.x
Subject(s) - sibling , german , haplotype , phenotype , genetics , microbiology and biotechnology , biology , genotype , gene , psychology , philosophy , developmental psychology , linguistics
The proposita in a German family of three siblings has D+ C+ c+ E‐ e+ f+ Rh: −17,19,33,34 red cells with weak C, e, f, Rh19, and Rh34 and stronger‐than‐usual Rh33 expression. One sibling has D+ C+ c+ E− e+ f+ Rh:17,19,33,34 red cells with weak f and ordinary‐strength Rh33, and the other sibling has D+ C+ c+ E− e+ f+ Rh:17,19,−33,34 red cells. In the absence of any further family members, the proposita's unusual phenotype suggests that she has an RoHar haplotype and a “new” Rh haplotype, provisionally named R1Lisa, that encodes Rh33, normal‐ strength D, weak C, weak or nondemonstrable e, Rh19, and Rh34, but not Rh17. Her Rh:33 sibling may have R 1 and R oHar and her Rh:−33 sibling R1 and r haplotypes.