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Suitable survival and half‐life of red cells after frozen storage in excess of 10 years
Author(s) -
Umlas J.,
Jacobson M.,
Kkevy S.V.
Publication year - 1991
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1991.31791368344.x
Subject(s) - blood preservation , medicine , andrology
To examine the appropriateness of the Food and Drug Administration's 10‐year storage time for previously frozen red cells, 24‐hour posttransfusion survival studies were performed, and the half‐life of 3 units of autologous red cells that had been stored for 13.5, 14, and 17 years, respectively, was measured. The units had acceptable freeze‐thaw‐ wash recovery (83.3–91.4%). When a 51 Cr label was used for the previously frozen red cells and a simultaneous 52 Cr label for freshly drawn autologous red cells was used as a comparison, it was seen that the previously frozen cells had normal 24‐hour posttransfusion survival (75.1–88.4%) as well as normal half‐life (23–33.7 days). These findings support further extension of the maximum allowable storage time for previously frozen red cells.