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Sia‐b1 and I antigens recognized by Mycoplasma pneumoniae ‐induced human cold agglutinins
Author(s) -
Roelcke D.,
Kreft H.,
Northoff H.,
Gallasch E.
Publication year - 1991
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1991.31791368339.x
Subject(s) - cold agglutinin , mycoplasma pneumoniae , antigen , virology , mycoplasma , microbiology and biotechnology , immunology , biology , mycoplasmataceae , mollicutes , medicine , antibody , pneumonia
Postinfection cold agglutinins (CAs) with anti‐Sia‐b1 (i.e., anti‐ Sia lo‐ branched) specificity frequently occurring together with anti‐I CAs recognize antigenic determinants that are present on O h red cells and are partially destroyed by endo‐β‐galactosidase on the red cell surface. They differ markedly from the monoclonal anti‐Sia‐b1 FI CA, which recognizes an epitope not expressed on O h cells, and resistant to the enzyme. On the other side, Sia‐b1 determinants reacting with postinfection CAs share the characteristics of I determinants, with the exception that Sia‐b1 determinants require sialyl groups as an immunodominant component. Five sera containing coexisting anti‐Sia‐b1 and anti‐I CAs were tested against O h and enzyme‐treated group O red cells. The results are consistent with a postinfection autoimmune response against a sialo‐type 2 structure common for Sia‐b1 and I determinants, which could serve as a receptor for Mycoplasma pneumoniae .