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Hemolytic transfusion reaction following transfusion of frozen and washed autologous red cells
Author(s) -
Cregan P.,
Donegan E.,
Gotelli G.
Publication year - 1991
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1991.31291142950.x
Subject(s) - hemolysis , medicine , red cell , fresh frozen plasma , hemolytic anemia , transfusion reaction , red blood cell , nephrotoxicity , blood transfusion , anesthesia , immunology , kidney , platelet
A case of hemolytic transfusion reaction, accompanied by hypotension and followed by transient renal failure, occurred after the transfusion of 1 unit of previously frozen autologous red cells. Subsequent investigation revealed the probable cause of the hemolysis to be inadequate deglycerolization of the unit. The cause of the associated symptoms is unknown. Possibilities include nephrotoxic effects of hemoglobin or stroma, toxic effects of glycerol, or release of vasoactive or thrombogenic substances from lysed red cells. This case of a hemolytic reaction adds to the known risks of autologous transfusion.