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Incubation of platelet concentrates before transfusion does not improve posttransfusion recovery
Author(s) -
Hussein M. A.,
Schiffer C. A.,
Lee E. J.
Publication year - 1990
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1990.30891020327.x
Subject(s) - incubation , medicine , platelet , incubation period , platelet transfusion , surgery , anesthesia , chemistry , biochemistry
Incubation of stored platelet concentrates (PCs) at 37 degrees C for 1 hour has been reported to result in a better morphology score and improved platelet recovery. A study was conducted in adult patients with leukemia to determine whether incubation of stored PCs results in an improved platelet recovery as measured by 10‐minute posttransfusion corrected count increments (CCI). Eligible patients had platelet counts of less than 30,000 per microL and were clinically stable. Patients were transfused with 6 to 10 units of PC stored for 3 days (15 studies) or 4 days (5 studies). Platelets were pooled and then split in two equal volumes so that each patient received two sequential half‐ transfusions, one incubated at 37 degrees C for 1 hour and the other kept at 22 degrees C for 1 hour. Patients were randomized as to which half‐transfusion was received first. The mean CCI of the incubated half‐ transfusions was 13.6 × 10(3) when they were given first and 14.5 × 10(3) when given second; this was not significantly different from the mean CCI of the nonincubated half‐transfusions: 13.8 × 10(3) when they were given first and 13.8 × 10(3) when given second. In contrast to earlier reports, it can be concluded that incubation of pooled PCs does not improve platelet recovery.