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UMC, another Cromer‐related blood group antigen
Author(s) -
Daniels G.L.,
Okubo Y.,
Yamaguchi H.,
Seno T.,
Ikuta M.
Publication year - 1989
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1989.29990070184.x
Subject(s) - antigen , trypsin , antibody , microbiology and biotechnology , glycoprotein , complement (music) , cell , chemistry , biology , phenotype , virology , immunology , biochemistry , enzyme , gene , complementation
An antibody found in the serum of a Japanese blood donor detects a new high‐frequency red cell antigen named UMC. UMC is absent from Inab phenotype cells, weakly expressed on Dr(a‐) cells, and destroyed by α‐chymotrypsin but not trypsin treatment of red cells. UMC is, therefore, a Cromer‐related antigen. Immunoblotting with anti‐UMC showed that UMC antigen, in common with other Cromer‐related antigens, is carried on a red cell surface glycoprotein with an apparent molecular weight of 70,000, which presumably is the complement regulatory protein decayaccelerating factor.