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Evidence that SE is distal to LU on chromosome 19q
Author(s) -
Zelinski T.,
Coghlan G.,
Greenberg C. R.,
McAlpine P. J.,
Lewis M.
Publication year - 1989
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1989.29489242794.x
Subject(s) - locus (genetics) , complement (music) , genetics , chromosome , biology , gene , phenotype , complementation
Analysis of a family informative for chromosome 19 loci establishes that the Lutheran blood group locus ( LU ) lies between the third component of human complement ( C3 ) and the secretor loci ( SE ). Previously published lod scores for C3:LU are increased from 2.94 to 3.80. The linkage relationships (ẑ and Ô ) between C3, LU , and SE are examined, and the proposed order and approximate genetic distances are determined to be: pter — C3 ‐ 10.6cM ‐ cen ‐ 7.4cM ‐ LU ‐ 9cM ‐ SE — qter.