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Antibody to c antigen consequent to renal transplantation
Author(s) -
Hjelle B.,
Donegan E.,
Cruz J.,
Stites D.
Publication year - 1988
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1988.28588337346.x
Subject(s) - transplantation , medicine , antibody , isoantibodies , immunology , antigen , histocompatibility testing , kidney transplantation , human leukocyte antigen
A case of apparent red cell (RBC) autoimmunity due to anti‐c is described in the recipient of a cadaveric renal transplant. Although the patient suffered little hemolysis as a result, a strong direct anti‐ c agglutinin was detectable on the patient's RBCs 8 days after transplantation and in his serum only 4 days after transplantation. We believe that the antibody was produced by passively transferred B lymphocytes in the donor kidney, and that the recipient may have been protected from more serious hemolysis by immunosuppressive agents administered at the time of transplantation. The donor received multiple transfusions before transplantation, but his serum lacked anti‐ c in a screen performed shortly before his death. This case raises the possibility that donor alloantibodies to other Rh antigens on recipient RBCs can arise after transplantation, if the donor has been transfused.