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Antibody response in an ABO‐incompatible blood transfusion
Author(s) -
Rydberg L.,
Breimer M. E.,
Samuelsson B. E.
Publication year - 1988
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1988.28588337343.x
Subject(s) - abo blood group system , antibody , antigen , agglutination (biology) , immunology , radioimmunoassay , blood type (non human) , titer , medicine , blood transfusion
The anti‐A response in a group B patient accidentally given 1 unit transfusion of A1 blood is described. The antibody response is characterized both with conventional agglutination techniques and with radioimmunoassay using pure group A antigens with different core saccharide structures (type 1, 2, and 4 chains) and class‐specific second antibodies. The anti‐A titer rose to a maximum Days 11 to 14 after the incompatible transfusion. The antibodies involved were mainly of the IgG and IgA types, while the IgM response was moderate. The IgA antibodies seemed to be nonselective with respect to group A antigen type, while the IgG antibodies showed a specificity against type 2 chain group A antigens.