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Studies on the blood of a Dc(e) homozygote and her family
Author(s) -
Issitt P. D.,
Smith D. L.,
McCollister L. S.,
Wren M. R.,
Ballas S. K.
Publication year - 1988
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1988.28588337332.x
Subject(s) - antigen , gene , immunology , medicine , biology , genetics , microbiology and biotechnology
It has been reported previously that genes that have been called Dc‐ represent a heterogeneous group and that some of them would better be described as Dc[e] and Dc(e). We have studied the blood of a black proposita and some of her family members and have concluded that she is homozygous for Dc(e). The form of Dc(e) present in this family makes all the Rh antigens of common occurrence for which we were able to test. In this respect, it differs markedly from another form of Dc(e), which is seen in individuals whose red cells lack a very common Rh antigen and who become immunized against that antigen. We suggest the term Dc(e)R 17 for the gene present in the family studied; our results indicate that its products are: normal amounts of D, c, G, Hr 0 , and Rh29; reduced amounts of e and f; and markedly reduced amounts of hr S and hr B . The expression of some antigens encoded by Dc(e)R 17 are quantitatively but not qualitatively different from the products of R0.