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An autologous fibrinogen‐based adhesive for use in otologic surgery
Author(s) -
Silberstein L.E.,
Williams L.J.,
Hughlett M.A.,
Magee D.A.,
Weisman R.A.
Publication year - 1988
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1988.28488265257.x
Subject(s) - fibrinogen , adhesive , medicine , surgery , blood product , autologous blood , materials science , layer (electronics) , composite material
Successful middle ear surgery requires the availability of a safe, effective bonding material. Side effects caused by synthetic materials have led to the use of biologic adhesives; however, they carry the risk of transmission of infectious disease if they are prepared from pooled human blood. A procedure for the production of an autologous fibrinogen‐based adhesive using polyethylene glycol to precipitate the fibrinogen‐factor XIII component from plasma is described. This procedure requires 40 ml of whole blood and approximately 3 hours' preparation time, and it can be performed in any blood bank with the facilities for sterile techniques. This adhesive has been used successfully for otologic surgery in 12 patients, and further study of the use of this biologic adhesive for other microsurgical techniques should be undertaken.