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Seroconversion to human immunodeficiency virus (HIV) in hemophiliacs
Author(s) -
Andes W. A.,
Daul C. B.,
Deshazo R. D.,
Palmer C. H.
Publication year - 1988
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1988.28288179040.x
Subject(s) - seroconversion , medicine , asymptomatic , generalized lymphadenopathy , viral disease , immunology , immunopathology , virus , natural history , antibody , disease , virology , aids related complex , lymphoma
The authors studied the natural history of human immunodeficiency virus (HIV) exposure in 187 hemophiliacs followed for an average of 45 months. Overall, 55 percent developed antibody specific for HIV and 21 percent developed persistent generalized lymphadenopathy. Most patients seroconverted sometime between early 1982 and the end of 1984. Four patients developed acquired immune deficiency syndrome (AIDS) and four seropositive patients developed idiopathic thrombocytopenia (ITP). One of the four patients who developed AIDS and three of the four with ITP had preexisting lymphadenopathy. None of the 10 patients with lymphadenopathy or the 20 asymptomatic patients was seropositive for human T‐lymphotropic virus, type I. Although seropositivity and lymphadenopathy have been found in many of the authors’ patients, few have developed clinical disease that can be related to HIV infection.