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Posttransfusion thrombocytopenia associated with passive transfusion of a platelet‐specific antibody
Author(s) -
Scott E.P.,
MoilanBergeland J.,
Dalmasso A.P.
Publication year - 1988
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1988.28188127960.x
Subject(s) - medicine , platelet , antibody , platelet transfusion , immunology , titer , blood transfusion , transfusion reaction
A transfusion reaction in a 76‐year‐old man was followed by severe but transient thrombocytopenia after infusion of whole blood. A high‐titer platelet‐specific antibody (anti‐PLA) was demonstrated in the plasma of the implicated unit and in the serum of the blood donor. In addition, three previous recipients of blood from the implicated donor had posttransfusion episodes of unexplained thrombocytopenia. These cases represent the first reported clinical examples of posttransfusion thrombocytopenia caused by passively transfused platelet‐specific alloantibodies.