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Recovery and survival in vivo of platelet concentrates prepared with prostaglandin E 1
Author(s) -
Menitove J.E.,
Kagen L.R.,
Aster R.H.
Publication year - 1988
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1988.28188127954.x
Subject(s) - platelet , adenylate kinase , prostaglandin e1 , in vivo , chemistry , cyclase , prostaglandin , prostaglandin e , platelet activation , prostaglandin e2 , blood product , andrology , endocrinology , medicine , biochemistry , surgery , biology , enzyme , microbiology and biotechnology
In follow‐up to previous studies showing that stimulators of adenylate cyclase inhibit the activation of platelets in platelet concentrates (PC), the posttransfusion recovery and survival of autologous platelets prepared and stored after the addition of prostaglandin E 1 (PGE 1 ) to platelet‐rich plasma at a concentration of 1.3 × 10 −8 M were investigated. Six normal subjects were studied on the two occasions, using PC stored with and without PGE 1 and radiolabeling with 51 Cr. The mean recovery of platelets prepared with PGE 1 (35.2 ± 8.1%) was significantly lower (p < 0.013) than that of routinely prepared platelet concentrates (46.3 ± 9.4%). The mean life‐spans of platelets prepared with and without PGE 1 were 7.1 ± 0.4 and 6.2 ± 1.0 days, respectively (p = NS). Despite its ability to inhibit the activation of platelets during concentration and storage, prostaglandin E 1 appears to reduce posttransfusion recovery of platelets significantly in this experimental model and cannot be recommended at this time as an adjunct for PC preparation.