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Xanthone additives for blood storage that maintain its potential for oxygen delivery
Author(s) -
Paterson R.A.,
Dawson J.,
Hyde R.M.,
Livingstone D.J.,
Parry E.S.,
Nash S.,
Boyce I.M.
Publication year - 1988
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1988.28188127948.x
Subject(s) - methemoglobin , chemistry , hemoglobin , hemolysis , xanthone , oxygen delivery , phosphate , alkoxy group , nuclear chemistry , oxygen , stereochemistry , biochemistry , medicine , organic chemistry , alkyl
Two xanthones, 2‐hydroxyethoxy‐6‐(5‐tetrazoyl) (BW A440C) and 2‐ethoxy‐ 6‐(5‐tetraozyl) (BW A827C), are members of a chemical series tested in vitro as potential additives to citrate‐phosphate‐dextrose‐adenine (CPDA‐1) medium for blood storage. P50 was maintained in the presence of these compounds during 42 days' storage by a partial maintenance of 2,3 diphosphoglycerate (2,3 DPG) and by a direct effect on hemoglobin previously reported for BW A827C. Red cell 2,3 DPG levels for BW A440C (n = 5), BW A827C (n = 5), and control (n = 6), respectively, were 3.38 ± 0.47, 3.44 ± 0.25, and 1.20 ± 0.10 mM ± SEM on day 7; 1.16 ± 0.13, 1.52 ± 0.37, and 0.16 ± 0.02 mM on day 21; and 0.67 ± 0.09, 0.61 ± 0.08, and 0.06 ± 0.006 mM on day 42. Red cell adenine triphosphate levels at the same time intervals were 1.84 ± 0.09, 1.46 ± 0.18, and 2.11 ± 0.04 mM; 2.10 ± 0.05, 2.07 ± 0.17, and 2.13 ± 0.05 mM; and 1.42 ± 0.13, 1.37 ± 0.13, and 1.38 ± 0.06 mM, respectively. The degree of hemolysis was less with the addition of the compounds, and the methemoglobin formation, plasma Na+ and K+, and lactate production were unaffected by the compounds.