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Hemolytic warm IgM autoagglutinins in autoimmune hemolytic anemia
Author(s) -
Freedman J.,
Wright J.,
Lim F.C.,
Garvey M.B.
Publication year - 1987
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1987.27688071695.x
Subject(s) - hemolysis , autoimmune hemolytic anemia , serology , fulminant , medicine , hemolytic anemia , coombs test , immunology , antibody , autoantibody , anemia
The authors report a patient with fulminant autoimmune hemolytic anemia due to a rare warm IgM autoagglutinin more reactive at 37 degrees C than at lower temperatures and secondary to systemic lupus erythematosis. The patient's clinical course and the serologic and immunochemical characteristics of the antibody are described, including the possibility that transfusions of small amounts of incompatible red cells may have contributed to the hemolysis. The consequences of using the initial serologic test results as the basis for therapy are discussed.