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Leukocyte depletion of red cell units at the bedside by transfusion through a new filter
Author(s) -
Sirchia G.,
Rebulla P.,
Parravicini A.,
Carnelli V.,
Gianotti G.A.,
Bertolini F.
Publication year - 1987
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1987.27587320533.x
Subject(s) - buffy coat , red cell , platelet , medicine , whole blood , red blood cell , red blood cell transfusion , filter (signal processing) , andrology , blood transfusion , surgery , immunology , anesthesia , computer science , computer vision
Standard packed red cell (PRC) units can be depleted of leukocytes and platelets if they are transfused through a blood administration set in which the usual 170‐mu filter has been replaced by a leukocyte removal filter (Sepacell R‐500). During a 6‐month period, 1550 PRC units were transfused through this filter in 611 transfusions to 80 multitransfused patients with thalassemia who had had a patient reaction rate (PRR) of 63 percent and a transfusion reaction rate (TRR) of 13 percent when given standard PRC or buffy‐coat‐depleted PRC. When given filtered PRC, PRR and TRR became 3.7 percent and 0.5 percent, respectively. The effectiveness of the filter was also evaluated in vitro. By filtering 2 standard PRC units through the same filter, median values (and ranges) for red cell recovery and for residual leukocytes and platelets were 87 percent (83–92), 6.1 × 10(6) (0–100), and 2.7 × 10(9) (0.6–9.7), respectively. Although refinements are needed to improve standardization of the filter and to increase red cell recovery (which is low when 1 unit is filtered through one filter) and blood administration rate, the ability to provide leukocyte‐free red cells prepared at the bedside for virtually all recipients appears to be a realistic goal.