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Evaluation of iron status in women identified by copper sulfate screening as ineligible to donate blood
Author(s) -
Morse Edward E.,
Cable Ritchard,
Pisciotto Patricia,
Kakaiya Ram,
Kiraly Thomas
Publication year - 1987
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1987.27387235628.x
Subject(s) - zinc protoporphyrin , medicine , hemoglobin , ferritin , iron status , venous blood , protoporphyrin , blood donor , iron deficiency , copper sulfate , serum ferritin , gastroenterology , physiology , anemia , immunology , chemistry , copper , biochemistry , heme , porphyrin , organic chemistry , enzyme
Assessment of venous hemoglobin (Hb), serum ferritin, and zinc protoporphyrin (ZPP) levels was carried out in women identified by CuSO4 screening as ineligible to donate blood. The correlation of log ferritin with ZPP was relatively poor (r = −0.580) but significant (p > than 0.01). However, a ZPP level of 2.0 micrograms per g Hb or greater (upper limit of normal for first‐time female donors) showed a predictive value of 0.85 for a ferritin level of 12 ng per ml or less in these donors. The correlation of hemoglobin concentration with ZPP level was significant (r = −0.667; p < than 0.001) in blood donors with ferritin levels at or below 12 ng per ml. ZPP level appears to be increased in iron‐depleted (hypoferritinemic) blood donor in whom animals had developed or was developing (Hb < than 12.5 g/dl). Although direct measurements of venous hemoglobin and ferritin levels most accurately evaluate such blood donors, these tests are time‐ consuming and expensive and are currently not adaptable to bloodmobile operations. Copper sulfate screening has proved feasible in the bloodmobile setting, and the measurement of ZPP level has been used for mobile screening for lead poisoning. ZPP may be an inexpensive and useful screening test to determine a subset of donors who should receive supplemental iron or reduce their frequency of blood donation.