Premium
A second Dr(a−) proposita with anti‐Dr a and a family with the Dr(a−) phenotype in two generations
Author(s) -
Levene C.,
Harel N.,
Kende G.,
Papo S.,
Bradford M.F.,
Daniels G.L.
Publication year - 1987
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1987.27187121478.x
Subject(s) - phenotype , judaism , allele , inheritance (genetic algorithm) , genetics , biology , gene , genealogy , history , theology , philosophy
An Israeli Jewish woman who originated from the Uzbekskaya SSR in the south of the Soviet Union, had anti‐Dr a in her serum and her red cells were Dr(a‐) as were those of three of her four children. All Dr(a‐) red cells had weakened expression of their Cr a , Tc a , Es a , IFC, and other Cromer‐related antigens. It is suggested that the Dr(a‐) phenotype may result from inheritance of a dominant inhibitor gene, although a relatively common recessive allele of Dr a was not excluded. Anti‐Dr a was inhibited by serums from the Dr(a+), but not the Dr(a‐), members of the family.