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Use of a control serum containing a low level of HBsAg for monitoring proficiency in screening for HBsAg
Author(s) -
Nath N.,
Wilkinson S.,
Dodd R. Y.
Publication year - 1986
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1986.26687043617.x
Subject(s) - hbsag , medicine , hepatitis b virus , hepatitis b , virology , virus
Aliquots of a serum preparation called “run control” containing low levels (1.4 ng/ml) of hepatitis B surface antigen (HBsAg) were tested by four American Red Cross Blood Services regions using a commercial test based on enzyme‐linked immunosorbent assay (EIA). The run control was tested a total of 424 and 892 times by procedures A and C, respectively, as recommended by the manufacturer (Abbott Laboratories, North Chicago, IL) of the EIA test kit. Results of all the tests were analyzed and showed that the run control was stable and reliable under field conditions. Illustrative examples of different approaches for the use of the run control in monitoring quality control of HBsAg testing are discussed.