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Anti‐Rh33, the second separable example, also made by a person who made anti‐D and has C+ red cells
Author(s) -
Issitt P. D.,
Wren M. R.,
McDowell M. A.,
Strohm P. L.,
Roberts T. M.
Publication year - 1986
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1986.26687043614.x
Subject(s) - medicine , separable space , mathematics , mathematical analysis
A complex serologic investigation resulted in identification of the second example of separable anti‐Rh33. A patient who had been transfused frequently and who had red cells that lacked a portion or portions of the D mosaic of antigens made anti‐D against that portion of D missing from her red cells, anti‐c, anti‐V, anti‐Rh33, anti‐K, and an autoantibody that mimicked the reactions of anti‐D. Differential adsorption experiments showed that the anti‐Rh33 was separable from the other antibodies present. The serologic findings in this case and in the study in which anti‐Rh33 was first found show some sort of relationship between D and Rh33. First, one of the genes, R oHar , that makes Rh33 makes a form of D that is difficult to detect. Second, the only other gene thus far known to make Rh33, D IV (C) —, encodes for a form of D from which portions of the D mosaic are missing. Third, both examples of separable anti‐Rh33 were made by women who made anti‐D and whose red cells were C+.