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Studies of the minimum temperature at which human platelets can be stored with full maintenance of viability
Author(s) -
Gottschall J. L.,
Rzad L.,
Aster R. H.
Publication year - 1986
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1986.26587020126.x
Subject(s) - platelet , life span , blood preservation , chemistry , andrology , zoology , surgery , medicine , biology , immunology , gerontology
Platelet concentrates from normal donors were stored for 3 days under identical conditions except for the temperature of storage, which was maintained at 21 ± 0.5, 19.5 ± 0.5, or 18 ± 0.5°C. Immediate posttransfusion recovery of the stored platelets determined by 51 Cr labeling averaged 47, 47, and 48 percent after storage at 21, 19.5, and 18°C, respectively (differences not significant). Mean life span of the transfused platelets, however, was 8.12, 5.21, and 1.85 days at 21, 19.5, and 18°C, respectively. The difference between mean life span following storage at 21°C was significantly different from that after storage at 18°C (p < 0.03). Reduction in viability after storage at the lower temperature correlated with the reduction in the number of discoid platelets. These findings indicate that platelet viability is compromised after storage for 3 days at 18° C and, possibly, at 19.5° C, and illustrate the need for quality control of temperature in short‐term platelet storage.