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The B 3 phenotype in Chinese
Author(s) -
LinChu M.,
Broadberry R. E.,
Chiou P. W.
Publication year - 1986
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1986.26587020118.x
Subject(s) - agglutination (biology) , polyclonal antibodies , avidity , group b , group a , antiserum , microbiology and biotechnology , monoclonal , monoclonal antibody , antigen , antibody , biology , medicine , immunology
Sixteen cases of subgroup B 3 and two cases of subgroup A 1 B 3 were found among donated blood processed in Taipei Blood Donation Center. The frequencies of B 3 and of A 1 B 3 among group AB Chinese in Taiwan are about 1 in 900, and about 1 in 1800, respectively. The B 3 red cells showed 1 to 2+ mixed field agglutination with anti‐B, 2 to 3+ mixed field agglutination with anti‐A,B, and 4+ agglutination with anti‐H. Reverse grouping showed anti‐A but no anti‐B activity; saliva of secretors contained B and H substances. The significant low avidity of subgroup B 3 and subgroup A 1 B 3 red cells with both polyclonal and monoclonal antiserums, as compared with normal group B cells, coupled with the difference in the avidity of the reaction between monoclonal and polyclonal antisera with B 3 and A 1 B 3 red cells, suggest the possibility of a qualitative as well as a quantitative difference in the B antigen of B 3 red cells.