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Recruitment of unrelated persons as bone marrow donors. A preliminary experience
Author(s) -
McElligott M. C.,
Menitove J. E.,
Aster R. H.
Publication year - 1986
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1986.26486262736.x
Subject(s) - confidentiality , medicine , bone marrow , human leukocyte antigen , sibling , histocompatibility testing , informed consent , immunology , histocompatibility , family medicine , antigen , psychology , pathology , alternative medicine , developmental psychology , political science , law
Seven hundred and sixty‐three blood donors previously typed for HLA‐A and B antigens were asked to consider donating bone marrow to unrelated patients for whom no HLA‐matched sibling was available. Eighty‐eight percent (668) indicated willingness to donate marrow, and of these, 615 (81%) participated in testing and 53 (7%) were unable to participate at the time of the request. Donors matched for HLA‐A, B, C, and DR antigens and compatible in the mixed‐leukocyte culture reaction were identified for 12 patients and eight transplants were performed. Engraftment was successful in all eight patients. In this article the factors considered in planning the program, the protocol eventually developed, the problems encountered, and critical issues of informed consent and donor confidentiality are reviewed.