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Plasma collection using an automated membrane device
Author(s) -
Rock G.,
Tittley P.,
McCombie N.
Publication year - 1986
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1986.26386209385.x
Subject(s) - plasmapheresis , centrifugation , hematocrit , chromatography , filtration (mathematics) , chemistry , membrane , ultrafiltration (renal) , platelet , fresh frozen plasma , medicine , immunology , biochemistry , antibody , mathematics , statistics
A plasmapheresis device with both membrane filtration and centrifugation features was tested. The device permits the collection of 500 ml of plasma within 30 minutes; when run at a 1:12.5 ratio with acid‐citrate‐dextrose (ACD‐A) the resultant plasma factor VIII levels were 1.05 units per ml and the albumin was 41 g per I. Free hemoglobin was not detected, and there was no evidence of fibrinopeptide A, prekallikrein, or activation of complement. The plasma had a zero hematocrit value and contained few platelets and white cells. Before and after the procedure, donors and aliquots from the return line did not show any significant effect on cell count or function. This device functioned well to collect plasma for infusion or fractionation and was accepted well by donors. A major advantage is the relatively low cost for the software package ($15.00, US, 1985), which should make plasmapheresis with this device economically feasible.