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Accelerated destruction of radiolabeled red cells due to anti‐Colton b
Author(s) -
Dzik W. H.,
Blank J.
Publication year - 1986
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1986.26386209380.x
Subject(s) - antibody , red cell , chemistry , isotopes of chromium , immunology , microbiology and biotechnology , medicine , biology
A patient who developed anti‐Co b in response to transfusion was studied. The antibody was a warm‐reactive, high‐titered, IgG alloantibody that did not fix complement, and reacted strongly in the antiglobulin phase. During a period of transfusion the patient developed a positive direct immunoglobulin test with anti‐Co b recoverable in the eluate. Reactions were stronger with enzyme‐treated red cells. Survival studies with 51 Chromium‐labeled red cells showed: 1) normal survival of Co(b‐) red cells, and 2) accelerated destruction of Co(b+) red cells; initially, cells were destroyed with a one‐half disappearance time of 4 days, but after about 4 days, the rate of destruction increased. This study, together with reported suspected transfusion reactions attributed to anti‐Co b , suggest that anti‐Co b should be considered a clinically significant antibody.