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Cold reacting antibodies recognizing antigens dependent on N− acetylneuraminic acid
Author(s) -
Staub C. A.
Publication year - 1985
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1985.25586020112.x
Subject(s) - cold agglutinin , antibody , antigen , immunology , n acetylneuraminic acid , isoantibodies , agglutinin , cold agglutinin disease , chemistry , medicine , sialic acid , biochemistry , autoantibody , lectin
Serum from a 75‐year‐old man with lymphoproliferative disease was found to contain a persistent cold agglutinin meeting most of the characteristics of examples of anti‐Gd reported previously. It differed, however, in that it contained IgG and IgM components and its reactivity was not inhibited by sialyllactose. A search of random serums containing cold agglutinins was undertaken to determine the incidence of antibodies to antigens dependent on N‐acetylneuraminic acid. Two further examples were found in 47 serums containing cold agglutinins. One of these also demonstrated a Gd or “Gd‐like” specificity. The other appeared to be an anti‐Pr.