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A clinically significant anti‐N in a patient whose red cells were negative for N and U antigens
Author(s) -
Ballas S. K.,
Dignam C.,
Harris M.,
Marcolina M. J.
Publication year - 1985
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1985.25485273821.x
Subject(s) - antigen , serology , red cell , mononuclear phagocyte system , peripheral blood mononuclear cell , immunology , hemolytic anemia , medicine , autoimmune hemolytic anemia , anemia , phagocyte , red blood cell , phenotype , sickle cell anemia , microbiology and biotechnology , antibody , biology , phagocytosis , in vitro , disease , gene , biochemistry
A patient with sickle cell anemia had M+N‐S‐s‐U‐phenotype and developed anti‐E, anti‐U, and anti‐N after multiple transfusions. The anti‐N was IgG, showed positive red cell mononuclear phagocyte assay, caused shortened survival of 51 Cr‐labeled N+ red cells, and incited a delayed hemolytic transfusion reaction. The anti‐U also caused decreased survival of U+ cells. The serological findings indicated that the anti‐ N recognized both N and ‘N’ antigens.