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Anti‐Tc b , an antibody that defines a red cell antigen antithetical to Tc a
Author(s) -
Lacey P. A.,
Block U. T.,
LairdFryer B. J.,
Moulds J. J.,
Bryant L. R.,
Giandelone J. A.,
Linnemeyer D. R.
Publication year - 1985
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1985.25485273820.x
Subject(s) - antigen , antibody , immunology , red cell , red blood cell , phenotype , isoantibodies , typing , medicine , biology , gene , genetics
A patient's serum, used as a source of anti‐Go a typing serum, was found to contain a second antibody that detected a ‘new” red cell antigen present in approximately 5 percent of blacks, but not yet found in Caucasians. Among blacks, the ‘new’ antigen shows an antithetical relationship to the high frequency antigen Tc a , as evidenced by tests on eight unrelated Tc(a‐) black women and the families of two of these propositi. The antigen, designated Tc b , has not been found on the red cells of Tc(a‐) persons whose racial origins differ from the propositi of this report, which suggests that more than one genetic mechanism can produce the Tc(a‐) phenotype. The presence of both anti‐Go a and anti‐ Tc b in the same serum appears to be a coincidental and unrelated finding.