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Replacement therapy for congenital Factor X deficiency
Author(s) -
Knight R. D.,
Barr C. F.,
Alving B. M.
Publication year - 1985
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1985.25185116511.x
Subject(s) - hemostasis , fresh frozen plasma , medicine , hemoperitoneum , surgery , platelet
We studied a young woman with severe (< 1%) congenital factor X deficiency during a 2‐year period in order to document the levels of factor X required to provide hemostasis for vaginal bleeding, epistaxis, and hemarthroses, as well as during surgery. Factor X levels of 9 to 17 percent, achieved with fresh‐frozen plasma (FFP) were satisfactory for minor bleeding. Hemostasis was achieved during emergency surgery for hemoperitoneum by increasing the factor X level to 35 percent with a Factor IX concentrate, followed with infusions of FFP to maintain levels between 10 and 20 percent for 6 days postoperatively. These data suggest that factor X levels of 10 to 20 percent are sufficient for hemostasis in factor X‐deficient patients even in the immediate postoperative period.