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The response of an acquired Factor V inhibitor to activated Factor IX concentrate
Author(s) -
Vickars L. M.,
Coupland R. W.,
Naiman S. C.
Publication year - 1985
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1985.25185116503.x
Subject(s) - prothrombin complex concentrate , refractory (planetary science) , fresh frozen plasma , medicine , prothrombin complex , factor ix , bleeding diathesis , platelet , hemorrhagic diathesis , gastroenterology , surgery , coagulation , warfarin , biology , astrobiology , atrial fibrillation
A 91‐year‐old man developed a severe bleeding diathesis postoperatively. Laboratory studies showed an inhibitor to factor V which was identified as IgG. The patient failed to respond to fresh‐ frozen plasma and platelet transfusions, but demonstrated both clinical and laboratory improvement after transfusion with an activated prothrombin complex concentrate (Autoplex). Patients with refractory inhibitors to factors VIII or IX have been managed successfully with this concentrate; however, this case demonstrates that is also may be of value in managing patients with refractory inhibitors to factor V.