Anti‐Do b implicated as the cause of a delayed hemolytic transfusion reaction

A 27‐year‐old, gravida 3, para 2 woman experienced a delayed hemolytic transfusion reaction. She had anti‐Do b in both serum and eluate 8 days after infusion of 6 units of Do(b+) red cells. No antibody had been detected prior to transfusion. By the 15th day after transfusion, there was no evidence of survival of red cells from any of the 6 units. Anti‐ C and anti‐M were demonstrated later, but 29 months after transfusion, no atypical antibodies were detectable. The evidence suggests anti‐Do b should be considered an antibody of potential clinical significance until contrary evidence becomes available.