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Preservation of red cell antigens during storage of blood with different anticoagulants
Author(s) -
Myhre B. A.,
Demaniew S.,
Nelson E. J.
Publication year - 1984
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1984.24685066809.x
Subject(s) - abo blood group system , antigen , antigenicity , chemistry , red blood cell , blood preservation , immunology , medicine , andrology , chromatography , biochemistry
A major concern when storing blood is that the antigens of the red cells will lose some of their reactivity in vitro. As part of a study of blood stored in newer anticoagulants, we tested the persistence of the ABO, Rh, Lewis, and P antigens. Blood was stored for 21 to 35 days in several anticoagulant‐preservative systems, such as citrate‐ phosphate‐dextrose and several additive solutions, while using bags of polyvinyl chloride plasticized with di(2‐ethyl hexyl) phthalate or tri (2‐ethyl hexyl) trimellitate. No significant loss of antigenicity occurred in the ABO and Rh systems, but antigens in the Lewis and P systems lost some reactivity during storage.